We have funding to support several pre- and post-doctoral positions. Examples of potential projects in chemical and structural biology area include the development of approaches to address novel targets or minimize side effects of current approaches. Additional examples of available projects include anti-tumor immune response pathways, such as regulation of tissue-specific and bone marrow-derived Treg cell development by small ubiquitin-like modifications, regulation of macrophage mediated tumor cell killing by small ubiquitin-like modifications, and translational studies in pancreatic, colorectal, and head and neck cancers, as well as addressing proteasome inhibitor resistance of multiple myeloma.