Selected Publications

A new immuno-oncology target – SUMOylation
Yuan Chen.
Trends in Cancer. May 11, 2023. DOI:10.1016/j.trecan.2023.04.010.

Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression.
Du L, Liu W, Rosen ST, Chen Y...
J Mol Biol. 2023 Mar 1. 435(5):167968. DOI: 10.1016/j.jmb.2023.167968.

Allosteric inhibition of ubiquitin-like modifications by a class of inhibitor of SUMO-activating enzyme
YJ Li, L Du, J Wang, R Vega, TD Lee, Y Miao, G Aldana-Masangkay, ...
Cell chemical biology 26 (2), 278-288. e6, 2019

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Z Lv, L Yuan, JH Atkison, KM Williams, R Vega, EH Sessions, ...
Nature communications 9 (1), 1-12, 2018

Sumoylation of RORγt regulates TH 17 differentiation and thymocyte development
Z He, J Zhang, Z Huang, Q Du, N Li, Q Zhang, Y Chen, Z Sun
Nature communications 9 (1), 1-18, 2018

Regulation of miR-34b/c-targeted gene expression program by SUMOylation
YJ Li, L Du, G Aldana-Masangkay, X Wang, R Urak, SJ Forman, ...
Nucleic acids research 46 (14), 7108-7123, 2018

SUMO-mediated regulation of NLRP3 modulates inflammasome activity
R Barry, SW John, G Liccardi, T Tenev, I Jaco, CH Chen, J Choi, ...
Nature communications 9 (1), 1-14, 2018

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ...
Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012

Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif a reversal of the bound orientation
J Song, Z Zhang, W Hu, Y Chen
Journal of Biological Chemistry 280 (48), 40122-40129, 2005

Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
J Song, LK Durrin, TA Wilkinson, TG Krontiris, Y Chen
Proceedings of the National Academy of Sciences 101 (40), 14373-14378, 2004