Selected Publications
Immune regulation by the SUMO family.
Tharuka MDN, Courelli AS, Chen Y.
Nat Rev Immunol.. 2025. 25(8):608-620, 2025.
Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway.
de la Torre Medina J, Joshi U, Sonowal H, Kuang Y, Ren T, Chen DH, Tharuka MDN, Nguyen-Ta K, Gros H, Mikulski Z, Chen Y., White RR.
Mol. Cancer Ther., in press.
Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment.
Erdem S, Lee HJ, Shankara Narayanan JSN, Tharuka MDN, De la Torre J, Ren T, Kuang Y, Abeywardana T, Li K, Berger AJ, Lowy AM, White RR, Chen Y.
Mol. Cancer Ther. . 23(11):1597-1612, 2024.
A new immuno-oncology target – SUMOylation
Yuan Chen.
Trends in Cancer. May 11, 2023. DOI:10.1016/j.trecan.2023.04.010.
Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression.
Du L, Liu W, Rosen ST, Chen Y...
J Mol Biol. 2023 Mar 1. 435(5):167968. DOI: 10.1016/j.jmb.2023.167968.
Allosteric inhibition of ubiquitin-like modifications by a class of inhibitor of SUMO-activating enzyme
YJ Li, L Du, J Wang, R Vega, TD Lee, Y Miao, G Aldana-Masangkay, ...
Cell chemical biology 26 (2), 278-288. e6, 2019
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Z Lv, L Yuan, JH Atkison, KM Williams, R Vega, EH Sessions, ...
Nature communications 9 (1), 1-12, 2018
Sumoylation of RORγt regulates TH 17 differentiation and thymocyte development
Z He, J Zhang, Z Huang, Q Du, N Li, Q Zhang, Y Chen, Z Sun
Nature communications 9 (1), 1-18, 2018
Regulation of miR-34b/c-targeted gene expression program by SUMOylation
YJ Li, L Du, G Aldana-Masangkay, X Wang, R Urak, SJ Forman, ...
Nucleic acids research 46 (14), 7108-7123, 2018
SUMO-mediated regulation of NLRP3 modulates inflammasome activity
R Barry, SW John, G Liccardi, T Tenev, I Jaco, CH Chen, J Choi, ...
Nature communications 9 (1), 1-14, 2018
Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ...
Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012
Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif a reversal of the bound orientation
J Song, Z Zhang, W Hu, Y Chen
Journal of Biological Chemistry 280 (48), 40122-40129, 2005
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
J Song, LK Durrin, TA Wilkinson, TG Krontiris, Y Chen
Proceedings of the National Academy of Sciences 101 (40), 14373-14378, 2004